1: 68 percent / H2 / Pd/C / methanol; tetrahydrofuran 2: AcOH / ethanol / Ambient temperature 3: NaCNBH3 / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Saari, Walfred S.; Wai, John S.; Fisher, Thorsten E.; Thomas, Craig M.; Hoffman, Jacob M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3792 - 3802
1: AcOH / ethanol / Ambient temperature 2: NaCNBH3 / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Saari, Walfred S.; Wai, John S.; Fisher, Thorsten E.; Thomas, Craig M.; Hoffman, Jacob M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3792 - 3802
1: 1.) n-BuLi, i-Pr2EtN / 1.) THF, hexane, from -70 deg C to -30 deg C, 2.) THF, hexane, from -70 deg C to RT 2: AcOH / ethanol / Ambient temperature 3: NaCNBH3 / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Saari, Walfred S.; Wai, John S.; Fisher, Thorsten E.; Thomas, Craig M.; Hoffman, Jacob M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3792 - 3802
