反应条件
1: 76 percent / NaHCO3, m-chloroperbenzoic acid / CH2Cl2 / 3 h / 5 °C
2: 91 percent / LiN3, NH4Cl / dimethylformamide; H2O / 32 h / 70 °C
3: 70 percent / ammonium formate / 10percent Pd/C / methanol / 2.5 h / Ambient temperature
4: 89 percent / HCl / dioxane / 2 h / Ambient temperature
View Scheme
参考文献
Kempf; Norbeck; Codacovi; Wang; Kohlbrenner; Wideburg; Paul; Knigge; Vasavanonda; Craig-Kennard; et al.
Journal of medicinal chemistry, 1990 , vol. 33, # 10 p. 2687 - 2689
