2-乙酰基-1,2,3,4-四氢异喹啉-3-甲酸合成路线 （共 10 条）
反应条件
sodium hydroxide in acetone T=20°C; 1 h;
参考文献
Grunewald, Gary L.; Romero, F. Anthony; Criscione, Kevin R.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 134 - 140
反应条件
potassium hydroxide in methanol 5 h; Heating;
参考文献
Ho, Bin; Michael Crider; Stables, James P
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 3 p. 265 - 286
反应条件
1: 43 percent / NaOMe / 4 h / Heating 2: 89 percent / KOH / aq. methanol / 5 h / Heating View Scheme
参考文献
Kammermeier; Lerch; Sommer
Synthesis, 1992 , # 11 p. 1157 - 1160
反应条件
1: 75 percent / NaOMe / 4 h / Heating 2: 1.) KOH, 2.) 2 N HCl / 1.) MeOH, H2O, reflux, 4 h, 2.) EtOAc, pH 1 View Scheme
参考文献
Kammermeier; Lerch; Sommer
Synthesis, 1992 , # 11 p. 1157 - 1160
反应条件
1: 86 percent / 6 N aq. HCl / 4 h / Heating 2: 83 percent / p-TsOH*H2O / toluene / 30 h / Heating 3: 94 percent / NaOH / methanol / 6 h / Ambient temperature View Scheme
参考文献
Kammermeier; Lerch; Sommer
Synthesis, 1992 , # 11 p. 1157 - 1160
反应条件
hydrogenchloride 4 h; Heating;
参考文献
Kammermeier; Lerch; Sommer
Synthesis, 1992 , # 11 p. 1157 - 1160
反应条件
1: 86 percent / 6 N aq. HCl / 4 h / Heating 2: 76 percent / p-TsOH*H2O / toluene / 30 h / Heating 3: 90 percent / NaOH / methanol / 6 h / Ambient temperature View Scheme
参考文献
Kammermeier; Lerch; Sommer
Synthesis, 1992 , # 11 p. 1157 - 1160
反应条件
1: 83 percent / aq. HCl / 5 h / Heating 2: 70 percent / Et3N / H2O; acetone View Scheme
参考文献
Ho, Bin; Michael Crider; Stables, James P
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 3 p. 265 - 286
反应条件
acetic anhydride
T=65 - 70°C; 1.5 h;
参考文献
Su, Tsann-Long; Chou, Ting-Chao
Patent: US2009/117125 A1, 2009 ;
Location in patent: Page/Page column 16 ;
US 20090117125 A1
反应条件
triethylamine in diethyl ether
T=70°C; 1 h;
参考文献
Sainsbury, Malcolm; Strange, Rosalind H.; Woodward, Peter R.; Barsanti, Paul A.
Tetrahedron, 1993 , vol. 49, # 10 p. 2065 - 2076
