4-(4,4-二甲基-2,5-二氧代咪唑烷-1-基)-2-三氟甲基苯甲腈合成路线 （共 10 条）
反应条件
1: 4-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)-benzonitrile With sodium hydride in N,N-dimethyl-formamide; mineral oil 0.25 h; 2: 4-bromo-1-acetoxybutane in N,N-dimethyl-formamide; mineral oil T=50°C; 2 h;
参考文献
Leonard, Matthew J.; Lingham, Anthony R.; Niere, Julie O.; Jackson, Neale R. C.; McKay, Peter G.; Huegel, Helmut M.
RSC Advances, 2014 , vol. 4, # 27 p. 14143 - 14148
反应条件
in N-methyl-acetamide; methanol; ethanol; dichloromethane; water
参考文献
Hoechst Marion Roussel
Patent: US6107488 A1, 2000 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=45°C; 48 h; Inert atmosphere;
参考文献
GEORGIA TECH RESEARCH CORPORATION; OYELERE, Adegboyega; GRYDER, Berkley
Patent: WO2012/50868 A1, 2012 ;
Location in patent: Page/Page column 26 ;
反应条件
1: phosgene; 4-amino-2-(trifluoromethyl)benzonitrile in toluene; acetonitrile
T=70°C;
2: tert-butyl 2-amino-2-methylpropanoate hydrochloride With triethylamine in toluene; acetonitrile
T=20°C;
3: With hydrogenchloride; water in toluene; acetonitrile
T=70°C; 1 h;
参考文献
SANOFI-AVENTIS
Patent: US2011/178134 A1, 2011 ;
Location in patent: Page/Page column 37 ;
反应条件
hydrogenchloride; water
0.583333 h; Heating / reflux;
参考文献
Labrie, Fernand; Breton, Rock; Singh, Shankar Mohan; Maltais, Rene
Patent: US2006/287327 A1, 2006 ;
Location in patent: Page/Page column 52-53 ;
反应条件
pyridine; oxygen; copper diacetate in dichloromethane
168 h;
参考文献
Huegel, Helmut M.; Rix, Colin J.; Fleck, Karin
Synlett, 2006 , # 14 p. 2290 - 2292
反应条件
18-crown-6 ether; sodium hydride in N,N-dimethyl-formamide
T=140°C; 60 h;
参考文献
Huegel, Helmut M.; Rix, Colin J.; Fleck, Karin
Synlett, 2006 , # 14 p. 2290 - 2292
反应条件
1: acetonitrile / 70 °C
2: triethylamine / acetonitrile / 0.75 h / 20 °C
3: hydrogenchloride / acetonitrile; water / 1 h / 70 °C
View Scheme
参考文献
SANOFI-AVENTIS
Patent: US2011/46105 A1, 2011 ;
反应条件
1: triethylamine / acetonitrile / 0.75 h / 20 °C
2: hydrogenchloride / acetonitrile; water / 1 h / 70 °C
View Scheme
参考文献
SANOFI-AVENTIS
Patent: US2011/46105 A1, 2011 ;
反应条件
1: sodium nitrite / N,N-dimethyl-formamide / 14 h / 20 °C
2: iron; hydrogenchloride / isopropyl alcohol; ethanol; water / 1 h / 90 °C
3: potassium carbonate / 1,2-dichloro-ethane / 14 h
4: sodium nitrite / N,N-dimethyl-formamide / 14 h / 20 °C
5: N,N-dimethyl-formamide / 7 h / 110 °C
View Scheme
参考文献
Leonard, Matthew J.; Lingham, Anthony R.; Niere, Julie O.; Jackson, Neale R. C.; McKay, Peter G.; Huegel, Helmut M.
RSC Advances, 2014 , vol. 4, # 27 p. 14143 - 14148
