2-羟基-4,5-二甲氧基苯甲醛合成路线 （共 33 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate P=760.051 Torr; 15 h;
参考文献
METHYLGENE, INC.
Patent: WO2005/30704 A1, 2005 ;
Location in patent: Page/Page column 225-226 ;
反应条件
1: With boron trichloride in dichloromethane T=-78 - 20°C; 3 h; 2: With hydrogenchloride; water in dichloromethane T=0°C;
参考文献
Laplace, Duchan R.; Verbraeken, Bart; Van Hecke, Kristof; Winne, Johan M.
Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 253 - 262
反应条件
1: With tetrabutyl ammonium fluoride T=20°C; 3 h; Inert atmosphere; 2: With water
参考文献
Yoshioka, Eito; Miyabe, Hideto
Tetrahedron, 2012 , vol. 68, # 1 p. 179 - 189
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate in N,N-dimethyl-formamide T=0°C; Vilsmeier formylation; 0.5 h; 2: 1-hydroxy-3,4-dimethoxybenzene T=0 - 90°C; Vilsmeier formylation;
参考文献
Signore, Giovanni; Nifosi, Riccardo; Albertazzi, Lorenzo; Storti, Barbara; Bizzarri, Ranieri
Journal of the American Chemical Society, 2010 , vol. 132, # 4 p. 1276 - 1288
反应条件
sodium hydroxide; boron trichloride in dichloromethane; benzene
参考文献
Glaxo Wellcome Inc.
Patent: US5910494 A1, 1999 ;
反应条件
boron tribromide in 1,2-dichloro-ethane T=-14 - 15°C; Fries rearrangement; 2 h;
参考文献
Ziegler, Georg; Haug, Erwin; Frey, Wolfgang; Kantlehner, Willi
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2001 , vol. 56, # 11 p. 1178 - 1187
反应条件
titanium tetrachloride in dichloromethane T=0°C; 2 h;
参考文献
Hirotani, Seiko; Kaji, Eisuke
Tetrahedron, 1999 , vol. 55, # 14 p. 4255 - 4270
反应条件
aluminium trichloride; acetyl chloride in dichloromethane T=-30°C; 0.5 h;
参考文献
Kelkar, Shriniwas L.; Phadke, Chetan P.; Marina, Sister
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 5 p. 458 - 459
反应条件
aluminium trichloride in dichloromethane 1 h; Ambient temperature;
参考文献
Mali, R. S.; Yadav, V. J.; Zaware, R. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, p. 759 - 760
反应条件
sulfuric acid Erhitzen der erhaltenen Diazoniumsalz-Loesung mit CuSO4;
参考文献
Arnold; Bordwell
Journal of the American Chemical Society, 1942 , vol. 64, p. 2983,2985
