1: C37H37N3O5S With Oxonereg; in water; N,N-dimethyl-formamide T=25°C; 2: (S)-tert-butyl 2-(hydroxyamino)propanoate in N,N-dimethyl-formamide T=40°C; Further stages.;

dimethyl sulfoxide T=120°C; 0.333333 h; Microwave irradiation;

1: N-Fmoc-L-leucine With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine Automated synthesizersolid phase reaction; 2: Automated synthesizersolid phase reaction; 3: N-(9-fluorenylmethoxycarbonyl)glycine; N-(fluoren-9-ylmethoxycarbonyl)-L-Val; N-Fmoc-L-leucine; N-(9H-fluoren-9-ylmethyloxycarbonylamino)-L-alanine; Fmoc-L-phenylalanine; fmoc-L-Ile-OH; N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc); N-(9-fluorenyl)methoxycarbonyl-Trp(Boc)-OH Further stages;

in diethyl ether; dichloromethane

1.1: Et3N; i-BuOCOCl / tetrahydrofuran / 0.25 h / -25 °C 1.2: 50 percent / tetrahydrofuran; diethyl ether / 0 - 20 °C 2.1: 71 percent / CF3COOAg; NMM / tetrahydrofuran; H2O / 8 h / 0 - 20 °C View Scheme

dimethyl sulfoxide T=120°C; 0.333333 h; Microwave irradiation;

1: N-Fmoc-D-Tyr(t-Bu)-OH With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine TentaGel RRAM solid phase resin; 2: With piperidine in N,N-dimethyl-formamide T=50°C; 1 h; 3: N-(9-fluorenylmethoxycarbonyl)glycine; N-Fmoc-L-leucine; N-(9H-fluoren-9-ylmethyloxycarbonylamino)-L-alanine; Fmoc–Pro–OH; Fmoc-L-phenylalanine; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; Fmoc-O-trityl-l-threonine; fmoc-Asn(trt)-OH; fmoc-Gln(Trt)-OH; Nα-Fmoc-N(im)-trityl-L-histidine; Fmoc-Asp(OMpe)-OH; N-(9-fluorenyl)methoxycarbonyl-Trp(Boc)-OH; fmoc-L-Arg(Pbf)-OH Further stages;