(5-氨基-4H-[1,2,4]噻唑-3-基)-乙酸合成路线 （共 5 条）
反应条件
1: With potassium hydroxide in water T=100°C; 2 h; 2: With hydrogenchloride in water pH=3 - 4;
参考文献
Abdel-Megeed, Ashraf M.; Abdel-Rahman, Hamdy M.; Alkaramany, Gamal-Eldien S.; El-Gendy, Mahmoud A.
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 1 p. 117 - 123
反应条件
1: With hydrogenchloride in water T=70°C; 2: With sodium hydroxide in water T=90 - 95°C; 0.666667 h; 3: With hydrogenchloride in water T=5°C; pH=2.5 - 2.7; 0.5 h;
参考文献
Russian Journal of Applied Chemistry, , vol. 82, # 2 p. 276 - 281
反应条件
1: With hydrogenchloride in water 2: With sodium hydroxide in water
参考文献
Zeitschrift fur Anorganische und Allgemeine Chemie, , vol. 637, # 11 p. 1453 - 1457
反应条件
potassium hydroxide 1.) water, 100 deg C, 4 h, 2.) water, 100 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Russian Journal of Organic Chemistry, , vol. 31, # 2 p. 240 - 244
Zhurnal Organicheskoi Khimii, , vol. 31, # 2 p. 270 - 275
反应条件
nitric acid; sodium nitrite in water T=50°C; 1 h;
参考文献
Thottempudi, Venugopal; Shreeve, Jean'Ne M.
Journal of the American Chemical Society, 2011 , vol. 133, # 49 p. 19982 - 19992
