7-氟-3-(肟基)吲哚啉-2-酮合成路线 （共 6 条）
反应条件
hydroxylamine hydrochloride in ethanol T=105°C; 2.5 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: US2008/318943 A1, 2008 ;
Location in patent: Page/Page column 68 ;
US 20080318943 A1
反应条件
1: With sulfuric acid T=74 - 76°C; 1.5 h; 2: With sodium sulfate; acetone in water; toluene T=20°C; 15 h; Product distribution / selectivity;
参考文献
US2006/247442 A1, ;
Page/Page column 6 ;
反应条件
trifluorormethanesulfonic acid Ambient temperature;
参考文献
Kearney; Harris; Jackson; Joule
Synthesis, 1992 , # 8 p. 769 - 772
反应条件
1: 84 percent / aq. ethanol / 24 h / Heating 2: 72 percent / aq.KOH / 5 h / Heating 3: 67 percent / CF3SO3H / Ambient temperature View Scheme
参考文献
Synthesis, , # 8 p. 769 - 772
反应条件
1: 72 percent / aq.KOH / 5 h / Heating 2: 67 percent / CF3SO3H / Ambient temperature View Scheme
参考文献
Synthesis, , # 8 p. 769 - 772
反应条件
in N,N-dimethyl-formamide T=20 - 180°C; 3 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: US2008/318943 A1, 2008 ;
Location in patent: Page/Page column 67-68 ;
US 20080318943 A1
