(2-溴-4-氯苯基)甲醇合成路线 （共 5 条）
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 2: With water; sodium carbonate in tetrahydrofuran
参考文献
WO2006/44454 A1, ;
Page/Page column 46-47 ;
WO 2006/044454 A1
反应条件
sodium tetrahydroborate in methanol 1 h; Cooling;
参考文献
WO2009/158426 A1, ;
Page/Page column 67-68 ;
WO 2009/158426 A1
反应条件
1: With diisobutylaluminium hydride in toluene T=-78 - 45°C; 2: With water; Potassium sodium tartrate in ethyl acetate; toluene T=-45 - 20°C; Product distribution / selectivity;
参考文献
WO2010/55005 A1, ;
Page/Page column 71-72 ;
WO 2010/055005 A1
反应条件
pyridinium chlorochromate in dichloromethane 2 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/44454 A1, 2006 ;
Location in patent: Page/Page column 47 ;
WO 2006/044454 A1
反应条件
phosphorus tribromide in diethyl ether 1 h; Cooling;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2009/158426 A1, 2009 ;
Location in patent: Page/Page column 68 ;
WO 2009/158426 A1
