1: With n-butyllithium in tetrahydrofuran T=-78 - 20°C; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water T=20°C; 1 h;

1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran T=-78 - 20°C; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water T=20°C; 1 h; Inert atmosphere;

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / 100 °C / Inert atmosphere 2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane; water / 100 °C / Inert atmosphere 3: toluene-4-sulfonic acid / methanol / 20 °C 4: triethylamine; methanesulfonyl chloride / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0 - 20 °C 5: trichlorophosphate / 1 h / 130 °C View Scheme

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / 100 °C / Inert atmosphere 2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane; water / 100 °C / Inert atmosphere 3: toluene-4-sulfonic acid / methanol / 20 °C 4: triethylamine; methanesulfonyl chloride / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0 - 20 °C View Scheme