1: With potassium hydroxide in dimethyl sulfoxide 4 h; 2: With water in dimethyl sulfoxide 0.5 h; 3: With hydrogenchloride in water; dimethyl sulfoxide T=0°C; pH=1;
参考文献
EMISPHERE TECHNOLOGIES, INC.
Patent: WO2005/112633 A2, 2005 ;
Location in patent: Page/Page column 89 ;
1: 1-benzyloxy-2-bromobenzene With magnesium; ethylene dibromide in tetrahydrofuran T=20°C; 2.5 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran 3: With hydrogenchloride in tetrahydrofuran; water
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sodium hydroxide in methanol; water T=60 - 70°C; Hydrolysis; 3 h;
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