sodium thiosulfate; sodium iodide in acetone 48 h; Heating;

1H-imidazole; iodine; triphenylphosphine in dichloromethane T=0 - 20°C; Iodination; 1 h;

1.1: DIBAL-H / hexane / 50 °C 1.2: 79 percent / I2 / tetrahydrofuran / -78 - 20 °C 2.1: DIBAL-H / hexane / 20 h / 50 °C 2.2: 67 percent / ZnCl2; Pd(PPh3)4 / tetrahydrofuran; hexane / 24 h / 0 °C 3.1: 91 percent / NaI; Na2S2O3 / acetone / 48 h / Heating View Scheme