4-氨基-2-氯-5-甲基嘧啶合成路线 （共 4 条）
反应条件
ammonia; N-ethyl-N,N-diisopropylamine in 1,4-dioxane; water T=100°C; 0.25 h; IrradiationCEM discover microwave at 100W;
参考文献
WO2004/74278 A1, ;
Page 31-33 ;
WO 2004/074278 A1
反应条件
caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane 3 h; Heating / reflux;
参考文献
TARGEGEN, INC.; TEFFERI, Ayalew
Patent: WO2012/60847 A1, 2012 ;
Location in patent: Page/Page column 42 ;
反应条件
1: With acetic acid
T=100°C; 2 h;
2: With sodium hydroxide in water
pH=~ 7; Product distribution / selectivity;
参考文献
TARGEGEN, INC.
Patent: WO2007/53452 A1, 2007 ;
Location in patent: Page/Page column 70 ;
WO 2007/053452 A1
反应条件
1: With acetic acid
T=100°C; 2.5 h;
2: With sodium hydroxide in water
参考文献
TARGEGEN, INC.
Patent: WO2007/53452 A1, 2007 ;
Location in patent: Page/Page column 104 ;
WO 2007/053452 A1
