N-bromosuccinmide in tetrachloromethane 12 h; Ambient temperature;

1: 95 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 1 h / 80 - 85 °C 2: 2) 40percent aq. KOH / 1) DMSO, THF, 0 deg C, 4 h, 2) r.t., 2 h View Scheme

1: 95 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 1 h / 80 - 85 °C 2: 100 percent / diethyl ether / 24 h / Ambient temperature 3: 68 percent / NaH / tetrahydrofuran / 1) 0 deg C, 1 h, 2) r.t., 24 h View Scheme