4-溴-6-硝基-2-哌嗪-1-基喹啉合成路线 （共 8 条）
反应条件
sulfuric acid in tetrahydrofuran T=80°C; 3 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 5 p. 811 - 815
反应条件
1: polyphosphoric acid / 2.5 h / 120 °C 2: phosphorus oxybromide / 3 h / 100 °C 3: 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 16 p. 4952 - 4959
反应条件
1: 56 percent / POBr3 / acetonitrile / 3 h / Heating 2: 71 percent / dimethylformamide / 3 h / 60 °C 3: aq. H2SO4 / tetrahydrofuran / 3 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 5 p. 811 - 815
反应条件
in N,N-dimethyl-formamide T=-10 - 3°C; 3 h;
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 44, p. S207 - S209
反应条件
1: 74 percent / 12 h / 150 °C 2: 36 percent / polyphosphoric acid / 3 h / 120 °C 3: 56 percent / POBr3 / acetonitrile / 3 h / Heating 4: 71 percent / dimethylformamide / 3 h / 60 °C 5: aq. H2SO4 / tetrahydrofuran / 3 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 5 p. 811 - 815
反应条件
1: 71 percent / dimethylformamide / 3 h / 60 °C 2: aq. H2SO4 / tetrahydrofuran / 3 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 5 p. 811 - 815
反应条件
1: phosphorus oxybromide / 3 h / 100 °C 2: 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 16 p. 4952 - 4959
反应条件
1: 36 percent / 3 h / 120 °C 2: 67 percent / 13 h / 120 °C / Heating 3: dimethylformamide / 3 h / -10 - 3 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 44, p. S207 - S209
