(S)-4-苄基-3-己酰-2-恶唑烷酮合成路线 （共 5 条）
反应条件
n-butyllithium in tetrahydrofuran; pentane T=-78 - 0°C; Acylation;
参考文献
Ponpipom, Mitree M.; Hagmann, William K.
Tetrahedron, 1999 , vol. 55, # 22 p. 6749 - 6758
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane
参考文献
Lan, Hong-Qiao; Ruan, Yuan-Ping; Huang, Pei-Qiang
Chemical Communications, 2010 , vol. 46, # 29 p. 5319 - 5321
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran 1 h; Ambient temperature;
参考文献
Ager, David J.; Allen, David R.; Schaad, David R.
Synthesis, 1996 , # 11 p. 1283 - 1285
反应条件
in tetrahydrofuran; pentane
参考文献
Merck and Co., Inc.
Patent: US5684152 A1, 1997 ;
US 5684152 A
反应条件
1: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 1 h, 2.) THF, a) -78 deg C, 1 h, b) -40 deg C, 1 h
2: 76 percent / aq. H2O2, LiOH / tetrahydrofuran / 3 h / 0 °C
View Scheme
参考文献
Levy, Daniel E.; Lapierre, France; Liang, Weisheng; Ye, Wenqing; Lange, Christopher W.; Li, Xiaoyuan; Grobelny, Damian; Casabonne, Marie; Tyrrell, David; Holme, Kevin; Nadzan, Alex; Galardy, Richard E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 2 p. 199 - 223
