1.1: NaNH2 / diethyl ether / 0.75 h 1.2: 87 percent / diethyl ether / 0.75 h 2.1: tBuOK; BuLi / hexane / 1 h / 25 °C 2.2: hexane / -75 - 25 °C 2.3: 36 percent / triethyl(methoxycarbonylsulfamoyl)ammonium hydroxide / hexane / 1 h / 25 °C View Scheme

1: (i) EtMgBr, (ii) /BRN= 2094622/ 2: (i) Ac2O, KOAc, (ii) TsOH View Scheme

1.1: NaNH2 / diethyl ether / 0.75 h 1.2: 87 percent / diethyl ether / 0.75 h 2.1: tBuOK; BuLi / hexane / 1 h / 25 °C 2.2: 54 percent / fluorodimethoxyborane diethyl etherate; H2O2 (30percent); NaOH (3.0 M) / hexane / 1 h / 25 °C View Scheme

1.1: hexane / 0 °C 1.2: 84 percent / tetrahydrofuran; hexane / -75 - 25 °C 2.1: 81 percent / triethyl(methoxycarbonylsulfamoyl)ammonium hydroxide / tetrahydrofuran / 0.25 h / 25 °C 3.1: LDA; NMPA / tetrahydrofuran; hexane 3.2: fluoromethoxyborane diethyl etherate; H2O2 (30percent); NaOH (3.0 M) / tetrahydrofuran / 2 h / 25 °C 3.3: 41 percent / pyridine / CH2Cl2 / 3 h / 25 °C View Scheme

1: 40 percent / 2,6-di-tert-butyl-4-methylpyridine / CH2Cl2 / 0 - 50 °C 2: 98 percent / Pd2(dba)3; AsPh3 / various solvent(s) / 0.5 h / 60 °C View Scheme

1: 73 percent / LiHMDS / tetrahydrofuran / -90 °C 2: 67 percent / pyridine / 1 h / Heating 3: 54 percent / POCl3, pyridine / toluene / 50 °C View Scheme