2,2,4-三甲基-1,3-戊二醇合成路线 （共 62 条）
反应条件
1: 2,2,4-trimethyl-1,3-pentanediol With potassium hexamethylsilazane in tetrahydrofuran T=0°C; 1 h; Inert atmosphere; 2: isobutyraldehyde in tetrahydrofuran T=55°C; Inert atmosphere; Reagent/catalyst; Overall yield = 92.5 percent; Overall yield = 6.637 g;
参考文献
Toermaekangas, Olli P.; Koskinen, Ari M. P.
Organic Process Research and Development, 2001 , vol. 5, # 4 p. 421 - 425
反应条件
1: 2,2,4-trimethyl-1,3-pentanediol With n-butyllithium in tetrahydrofuran Inert atmosphere; 2: isobutyraldehyde in tetrahydrofuran 0.533333 h; Inert atmosphere; SolventReagent/catalyst;
参考文献
Toermaekangas, Olli P.; Koskinen, Ari M. P.
Organic Process Research and Development, 2001 , vol. 5, # 4 p. 421 - 425
参考文献
Brannock; Lappin
Journal of the American Chemical Society, 1955 , vol. 77, p. 6052
反应条件
PTAB; N-benzyl-N,N,N-triethylammonium chloride; antimony(III)tribromide in dimethyl sulfoxide T=20°C; 61 h;
参考文献
Sayama, Shinsei
Tetrahedron Letters, 2006 , vol. 47, # 24 p. 4001 - 4005
反应条件
PTAB; N-benzyl-N,N,N-triethylammonium chloride; antimony(III)tribromide in dimethyl sulfoxide T=20°C; 46 h;
参考文献
Sayama, Shinsei
Tetrahedron Letters, 2006 , vol. 47, # 24 p. 4001 - 4005
反应条件
PTAB; N-benzyl-N,N,N-triethylammonium chloride; antimony(III)tribromide in dimethyl sulfoxide T=20°C; 42 h;
参考文献
Sayama, Shinsei
Tetrahedron Letters, 2006 , vol. 47, # 24 p. 4001 - 4005
反应条件
sulfuric acid Heating; Further byproducts given;
参考文献
Mazet,M.; Desmaison-Brut,M.
Bulletin de la Societe Chimique de France, 1971 , p. 2656 - 2662
反应条件
toluene-4-sulfonic acid in chloroform
参考文献
Schwenk,U.; Becker,A.
Justus Liebigs Annalen der Chemie, 1972 , vol. 756, p. 162 - 169
反应条件
1: 2,2,4-trimethyl-1,3-pentanediol With n-butyllithium in tetrahydrofuran Inert atmosphere; 2: isobutyraldehyde in tetrahydrofuran 0.533333 h; Inert atmosphere; SolventReagent/catalyst;
参考文献
Toermaekangas, Olli P.; Koskinen, Ari M. P.
Organic Process Research and Development, 2001 , vol. 5, # 4 p. 421 - 425
反应条件
tert.-butylhydroperoxide; [.pi.-C5H5N(+)(CH2)15CH3]3(PMo12O40)(3-) in benzene 24 h; Heating;
参考文献
Yamawaki, K.; Yoshida, T.; Nishihara, H.; Ishii, Y.; Ogawa, M.
Synthetic Communications, 1986 , vol. 16, # 5 p. 537 - 542
