1-(4-肼基苄基)-1H-1,2,4-噻唑合成路线 （共 7 条）
反应条件
sodium sulfite in water T=0 - 65°C; 1.75 h;
参考文献
WO2004/14877 A1, ;
Page 12-13; 15 ;
反应条件
1: With hydrogenchloride; sodium nitrite in water T=-5 - 0°C; 0.75 h; Saturated solution; 2: With sodium sulfite in water T=0 - 65°C; 17.25 h;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 48, # 4 p. 590 - 594
反应条件
1: 100 percent / H2, 2N aq. HCl / 10percent Pd/C / ethanol; ethyl acetate / 0.2 h / 2068.6 Torr 2: 1.) aq. NaNO2, conc. aq. HCl, 2.) SnCl2*2H2O, conc. aq. HCl / 1.) 0 deg C, 0.1 h, 2.) from -5 deg C to RT View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1799 - 1810
反应条件
1: 52 percent / dimethylformamide / 16 h / 25 °C 2: 100 percent / H2, 2N aq. HCl / 10percent Pd/C / ethanol; ethyl acetate / 0.2 h / 2068.6 Torr 3: 1.) aq. NaNO2, conc. aq. HCl, 2.) SnCl2*2H2O, conc. aq. HCl / 1.) 0 deg C, 0.1 h, 2.) from -5 deg C to RT View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1799 - 1810
反应条件
hydrogenchloride in ethanol 4 h; Heating;
参考文献
Street; Baker; Davey; Guiblin; Jelley; Reeve; Routledge; Sternfeld; Watt; Beer; Middlemiss; Noble; Stanton; Scholey; Hargreaves; Sohal; Graham; Matassa
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1799 - 1810
反应条件
1: With hydrogenchloride in water T=90°C; 1 h; 2: With sodium hydroxide in water pH=7;
参考文献
Mittapelli, Vasantha; Ray, Puma Chandra; Chauhan, Yogendra Kumar; Datta, Debashish
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 4 p. 590 - 594
反应条件
1: 4-(1,2,4-triazol-1-ylmethyl)phenylhydrazine With sulfuric acid T=65 - 70°C; Fischer Indole Synthesis; 2 h; 2: 4-(N,N-dimethylamino)butyraldehyde diethyl acetal T=20 - 70°C; Fischer Indole Synthesis; 3 - 4 h; 3: With ammonia; water T=15 - 20°C; pH=8.5 - 9;
参考文献
WO2008/149152 A1, ;
Page/Page column 13 ;
