2-(3-溴-4-异丁氧基苯基)-4-甲基噻唑-5-甲酸乙酯合成路线 （共 6 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80 - 85°C; 5 h;
参考文献
NATCO PHARMA LIMITED; Kompella, Amala; Gampa, Venue Gopala Krishna; Adibhatla, Kali Satya Bhujanga Rao; Nannapaneni, Venkaiah Chowdary
Patent: US2013/172571 A1, 2013 ;
Location in patent: Paragraph 0097; 0098; 0099; 0100 ;
反应条件
in ethanol 16 h; RefluxInert atmosphere;
参考文献
CHEMO IBERICA, S.A.; CASTALDI, Graziano; RASPARINI, Marcello; SILLANI, Laura
Patent: WO2010/142653 A1, 2010 ;
Location in patent: Page/Page column 16-17 ;
反应条件
1.1: hydrogenchloride / isopropyl alcohol / 0.25 h 1.2: 2 h / 50 - 55 °C 2.1: isopropyl alcohol / 5 h / 80 - 85 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 - 85 °C View Scheme
反应条件
1.1: hydroxylamine hydrochloride; sodium formate; formic acid / 5 h / 105 - 110 °C 2.1: hydrogenchloride / isopropyl alcohol / 0.25 h 2.2: 2 h / 50 - 55 °C 3.1: isopropyl alcohol / 5 h / 80 - 85 °C 4.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 - 85 °C View Scheme
反应条件
1: isopropyl alcohol / 5 h / 80 - 85 °C 2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 - 85 °C View Scheme
参考文献
WO2012/32528 A2, ;
US2013/172571 A1, ;
反应条件
copper(l) iodide in N,N-dimethyl-formamide T=130 - 140°C; 16 h;
参考文献
NATCO PHARMA LIMITED; Kompella, Amala; Gampa, Venue Gopala Krishna; Adibhatla, Kali Satya Bhujanga Rao; Nannapaneni, Venkaiah Chowdary
Patent: US2013/172571 A1, 2013 ;
Location in patent: Paragraph 0101 ;
