1: 97.6 percent / pyridine, Ac2O, CrO3 / CH2Cl2 / 0.08 h 2: 31.2 percent / diethyl ether / 0.17 h / 0 °C 3: 63 percent / N-methylimidazole / 0.5 h / 150 °C 4: SnCl4 / 1,2-dichloro-ethane / 15 h / Heating 5: 1.) CF3SO3SiMe3, 2.) NaOMe, MeOH / 1.) 1,2-dichloroethane, 15 min, reflux, 2.) 1,2-dichloroethane, 20 deg C, 1 h 6: 95 percent / pyridine / 0.17 h / Heating 7: 1.) SOCl2, 2.) NH3, methanol / 1.) reflux, 2 min, 2.) 20 deg C, 24 h View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103233', constants.ctx, '0')">pyridine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605264', constants.ctx, '0')">1,2-dichloro-ethane</a> <br />T=-5 - 0&deg;C;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '610776', constants.ctx, '0')">triphenylphosphine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '908662', constants.ctx, '0')">diethylazodicarboxylate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />48&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;&nbsp;Yield given. Yields of byproduct given. Title compound not separated from byproducts;&nbsp;<br /> &nbsp;