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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
2-溴-6-氟吡啶
合成路线
（共 25 条）
144100-07-2
2-溴-6-氟吡啶
+
74-88-4
甲基碘
→
反应条件
1211536-81-0
反应条件
1: 2-bromo-6-fluoro-pyridine With n-butyllithium; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; hexane T=-78 - 0°C; 3.5 h; 2: methyl iodide in tetrahydrofuran; hexane T=20°C; 1 h;
参考文献
F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; TSUI, Vickie, H.; WANG, Xiaojing
Patent: WO2014/1377 A1, 2014 ;
Location in patent: Page/Page column 139; 140 ;
144100-07-2
2-溴-6-氟吡啶
→
反应条件
1214335-26-8
反应条件
1.1: n-butyllithium; tri-isopropoxy-borane / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere 1.2: 4 h / 0 °C 2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; sodium carbonate / ethanol / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
Ren, Wei; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron, 2012 , vol. 68, # 5 p. 1351 - 1358
144100-07-2
2-溴-6-氟吡啶
→
反应条件
1214360-31-2
反应条件
1.1: n-butyllithium; tri-isopropoxy-borane / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere 1.2: 4 h / 0 °C 2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; sodium carbonate / ethanol / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
Ren, Wei; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron, 2012 , vol. 68, # 5 p. 1351 - 1358
144100-07-2
2-溴-6-氟吡啶
→
反应条件
1245645-95-7
反应条件
1.1: n-butyllithium; tri-isopropoxy-borane / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere 1.2: 4 h / 0 °C 2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; sodium carbonate / ethanol / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
Ren, Wei; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron, 2012 , vol. 68, # 5 p. 1351 - 1358
144100-07-2
2-溴-6-氟吡啶
→
反应条件
1223063-81-7
反应条件
1.1: n-butyllithium; tri-isopropoxy-borane / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere 1.2: 4 h / 0 °C 2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; sodium carbonate / ethanol / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
Ren, Wei; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron, 2012 , vol. 68, # 5 p. 1351 - 1358
144100-07-2
2-溴-6-氟吡啶
→
反应条件
1245648-43-4
反应条件
1.1: n-butyllithium; tri-isopropoxy-borane / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere 1.2: 4 h / 0 °C 2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; sodium carbonate / ethanol / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron, , vol. 68, # 5 p. 1351 - 1358
144100-07-2
2-溴-6-氟吡啶
→
反应条件
1245649-67-5
反应条件
1.1: n-butyllithium; tri-isopropoxy-borane / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere 1.2: 4 h / 0 °C 2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; sodium carbonate / ethanol / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
Ren, Wei; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron, 2012 , vol. 68, # 5 p. 1351 - 1358
144100-07-2
2-溴-6-氟吡啶
+
112275-50-0
1,4-二氮杂环庚烷-1-甲酸叔丁酯
→
反应条件
1152093-60-1
4-(6-溴吡啶-2-基)-1,4-二氮杂烷-1-羧酸叔丁酯
反应条件
N-ethyl-N,N-diisopropylamine in ethanol T=100°C; 16 h;
参考文献
F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; TSUI, Vickie, H.; WANG, Xiaojing
Patent: WO2014/1377 A1, 2014 ;
Location in patent: Page/Page column 103 ;
144100-07-2
2-溴-6-氟吡啶
→
反应条件
1177269-58-7
反应条件
1.1: n-butyllithium; tri-isopropoxy-borane / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere 1.2: 4 h / 0 °C 2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; sodium carbonate / ethanol / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
Ren, Wei; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron, 2012 , vol. 68, # 5 p. 1351 - 1358
50-00-0
甲醛
+
144100-07-2
2-溴-6-氟吡啶
→
反应条件
1227563-78-1
6-溴-2-氟-3-吡啶甲醇
反应条件
1: 2-bromo-6-fluoro-pyridine With n-butyllithium; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; hexane T=-78 - 0°C; 3 h; 2: formaldehyd in tetrahydrofuran; hexane T=20°C; 3: With water in tetrahydrofuran; hexane
参考文献
F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; TSUI, Vickie, H.; WANG, Xiaojing
Patent: WO2014/1377 A1, 2014 ;
Location in patent: Page/Page column 145; 146 ;
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