7-氯-10-乙基-3-[4-(三氟甲基)苯基]-3,4-二氢-1,9(2H,10H)-吖啶二酮合成路线 （共 3 条）
反应条件
1: 32 percent / 50percent aq. NaOH / 72 h / Ambient temperature 2: EtONa / ethanol / 6 h / Heating 3: 2 N NaOH / 2 h / Heating 4: 5 N H2SO4 / 4.5 h / Heating 5: 1.) 50percent NaH / 1.) DMF, RT, 1 h, 2.) DMF, 90 deg C, 4 h View Scheme
参考文献
Kesten, Stephen J.; Degnan, Margaret J.; Hung, Jocelyn; McNamara, Dennis J.; Ortwine, Daniel F.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 19 p. 3429 - 3447
反应条件
1: EtONa / ethanol / 6 h / Heating 2: 2 N NaOH / 2 h / Heating 3: 5 N H2SO4 / 4.5 h / Heating 4: 1.) 50percent NaH / 1.) DMF, RT, 1 h, 2.) DMF, 90 deg C, 4 h View Scheme
参考文献
Kesten, Stephen J.; Degnan, Margaret J.; Hung, Jocelyn; McNamara, Dennis J.; Ortwine, Daniel F.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 19 p. 3429 - 3447
反应条件
sodium hydride 1.) DMF, RT, 1 h, 2.) DMF, 90 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Kesten, Stephen J.; Degnan, Margaret J.; Hung, Jocelyn; McNamara, Dennis J.; Ortwine, Daniel F.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 19 p. 3429 - 3447
