1-叔丁氧羰基-4-氨甲基哌啶合成路线 （共 27 条）
反应条件
in chloroform T=0 - 20°C; 48 h;
参考文献
PALAU PHARMA, S. A.
Patent: WO2008/119792 A1, 2008 ;
Location in patent: Page/Page column 70 ;
WO 2008/119792 A1
反应条件
1: 4-(aminomethyl)-piperidine With benzaldehyde in toluene 4 h; Heating / reflux; 2: di-tert-butyl dicarbonate in toluene T=20°C;
参考文献
BIO-MEDISINSK INNOVASJON AS; COCKBAIN, Julian
Patent: WO2007/7072 A1, 2007 ;
Location in patent: Page/Page column 48-49 ;
WO 2007/007072 A1
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Levesque, Sophie; St-Denis, Yves; Bachand, Benoit; Preville, Patrice; Leblond, Lorraine; Winocour, Peter D; Edmunds, Jeremy J; Rubin; Siddiqui
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 24 p. 3161 - 3164
反应条件
potassium hydrogensulfate
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 8 p. 2195 - 2202
反应条件
hydrazine hydrate in ethanol
参考文献
Yoneda, Yoshiyuki; Mimura, Tetuya; Kawagoe, Keiichi; Yasukouchi, Takanori; Tatematu, Toshiaki; Ito, Masayuki; Saito, Masaki; Sugimura, Masunobu; Kito, Fusako; Kawajiri, Shinichi
Bioorganic and medicinal chemistry, 2002 , vol. 10, # 5 p. 1347 - 1359
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; Product distribution / selectivity;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2004/2483 A1, 2004 ;
Location in patent: Page/Page column 21-22 ;
WO 2004/002483 A1
反应条件
sodium hydroxide; benzaldehyde in toluene
参考文献
US5864039 A1, ;
US 5864039 A
反应条件
triethylamine in chloroform
参考文献
US6214832 B1, ;
US 6214832 B1
反应条件
water; acetic acid; zinc in ethanol
参考文献
US2010/93668 A1, ;
Page/Page column 48 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78 - 20°C; 0.5 h;
参考文献
Agouron Pharmaceuticals, Inc.
Patent: EP1215208 A2, 2002 ;
Location in patent: Example J(4) ;
EP 1215208 A2
