1-叔丁氧羰基-4-氨甲基哌啶合成路线 （共 27 条）
反应条件
1.1: triethylamine / methanol / 2 h / 0 - 20 °C 2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 3.1: sodium azide / N,N-dimethyl-formamide / 6 h / 120 °C 4.1: triphenylphosphine / tetrahydrofuran / 2 h / Reflux 4.2: 3 h / Reflux View Scheme
参考文献
WO2011/132901 A2, ;
WO 2011/132901 A2
反应条件
1.1: Et3N 2.1: aq. NaOH 3.1: ClCOO-i-Bu; N-methylmorpholine 3.2: aq. NH3 4.1: LiAlH4 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 5 p. 757 - 761
反应条件
1.1: aq. NaOH 2.1: ClCOO-i-Bu; N-methylmorpholine 2.2: aq. NH3 3.1: LiAlH4 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 5 p. 757 - 761
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 2 h;
参考文献
VENTIRX PHARMACEUTICALS, INC.; ARRAY BIOPHARMA, INC.; HOWBERT, James, Jeffry; DIETSCH, Gregory; HERSHBERG, Robert; BURGESS, Laurence, E.; LYSSIKATOS, Joseph, P.; NEWHOUSE, Brad; YANG, Hong, Woon
Patent: WO2011/22508 A2, 2011 ;
Location in patent: Page/Page column 52; 53 ;
WO 2011/022508 A2
参考文献
Merck and Co., Inc.
Patent: US6143750 A1, 2000 ;
US 6143750 A
反应条件
sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane
T=20°C; 3 h;
参考文献
Budzik, Brian; Garzya, Vincenzo; Shi, Dongchuan; Walker, Graham; Lauchart, Yann; Lucas, Adam J.; Rivero, Ralph A.; Langmead, Christopher J.; Watson, Jeannette; Wu, Zining; Forbes, Ian T.; Jin, Jian
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3545 - 3549
反应条件
potassium carbonate in acetonitrile
T=120°C; 0.5 h; Microwave irradiation;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2009/44162 A1, 2009 ;
Location in patent: Page/Page column 170 ;
WO 2009/044162 A1
