(9CI)-1-[(2R)-2-吡咯烷羰基]-吡咯烷合成路线 （共 5 条）
反应条件
palladium monocarbide in methanol
参考文献
SUGEN, INC.
Patent: WO2004/76412 A2, 2004 ;
Location in patent: Page 98 ;
WO 2004/076412 A2
反应条件
trifluoroacetic acid in dichloromethane 0.833333 h; Ambient temperature;
参考文献
Costa, Brian R. de; Dominguez, Celia; He, Xiao-shu; Williams, Wanda; Radesca, Lilian; Bowen, Wayne
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4334 - 4343
反应条件
1: 70 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, hydroxybenzotriazole (HOBT) / CH2Cl2 / Ambient temperature 2: 100 percent / TFA / CH2Cl2 / 0.83 h / Ambient temperature View Scheme
参考文献
Costa, Brian R. de; Dominguez, Celia; He, Xiao-shu; Williams, Wanda; Radesca, Lilian; Bowen, Wayne
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4334 - 4343
反应条件
1.1: s-butyllithium; (-)-sparteine / diethyl ether; cyclohexane / 5 h / -78 °C 1.2: diethyl ether; cyclohexane / 0.08 h / -78 °C 2.1: trifluoroacetic acid / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Harrison; O'Brien
Synthetic Communications, 2001 , vol. 31, # 8 p. 1155 - 1160
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 4 h; Heating;
参考文献
Costa, Brian R. de; Dominguez, Celia; He, Xiao-shu; Williams, Wanda; Radesca, Lilian; Bowen, Wayne
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4334 - 4343
