(S)-(2,2-二甲基-1,3-二氧环戊烷-4-基)甲基 3-(4-羟基苯基)丙酸酯合成路线 （共 6 条）
反应条件
potassium hydroxide in dimethyl sulfoxide T=100°C; 1 h;
参考文献
Iguchi; Iwamura; Nishizaki; Hayashi; Senokuchi; Kobayashi; Sakaki; Hachiya; Ichioka; Kawamura
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 6 p. 1462 - 1469
反应条件
sodium hydroxide in isopropyl alcohol T=30 - 40°C; pH=10 - 11;
参考文献
EP2687521 A1, ;
Paragraph 0043; 0044 ;
反应条件
1: 80 percent / K2CO3 / dimethylformamide / 15 h / 70 °C 2: 68 percent / propan-2-ol / 15 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 6 p. 1462 - 1469
反应条件
1: (S)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-hydroxyphenyl)propanoate; epichlorohydrin With Jacobsen's (R,R)-(salen)Co(III) catalyst; 4-nitro-benzoic acid in dichloromethane; tert-butyl methyl ether T=20 - 25°C; 2: With potassium carbonate; potassium iodide in acetonitrile 2 h; Reflux; 3: 2-(morpholine-4-carboxamido)ethanamino oxalate Further stages;
参考文献
Procos S.p.A.; Garavaglia, Fabio; Roletto, Jacopo; Paissoni, Paolo
Patent: EP2687521 A1, 2014 ;
Location in patent: Paragraph 0053; 0054; 0055; 0056; 0057 ;
反应条件
1.1: 4-nitro-benzoic acid; Jacobsen's (R,R)-(salen)Co(III) catalyst / tert-butyl methyl ether / 20 - 25 °C 2.1: potassium carbonate; potassium iodide / acetonitrile / 2 h / |Reflux 2.2: |Reflux 3.1: hydrogenchloride / isopropyl alcohol View Scheme
参考文献
Procos S.p.A.; Garavaglia, Fabio; Roletto, Jacopo; Paissoni, Paolo
Patent: EP2687521 A1, 2014 ;
反应条件
1: sodium hydroxide / isopropyl alcohol / 30 - 40 °C / pH 10 - 11 2: hydrogenchloride / isopropyl alcohol View Scheme
参考文献
Procos S.p.A.; Garavaglia, Fabio; Roletto, Jacopo; Paissoni, Paolo
Patent: EP2687521 A1, 2014 ;
