1: acetoacetic acid methyl ester With n-butyllithium; sodium hydride in tetrahydrofuran T=0°C; 2: dodecyl bromide in tetrahydrofuran T=0 - 20°C;
参考文献
Burnham Institute for Medical Research; The Texas A and M University System
Patent: US2009/124681 A1, 2009 ;
Location in patent: Page/Page column 11-12 ;
US 20090124681 A1
1: mono-methyl malonate potassium salt With triethylamine; magnesium chloride in acetonitrile T=20°C; 3 h; 2: myristic acid chloride With triethylamine in acetonitrile T=20°C; 20 h; Further stages.;
1: n-tetradecanoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 10 h; 2: magnesium salt of monomethyl malonic acid in tetrahydrofuran T=20°C; 18 h; Further stages.;
参考文献
Ratovelomanana-Vidal; Girard; Touati; Tranchier; Ben Hassine; Genet
Advanced Synthesis and Catalysis, 2003 , vol. 345, # 1-2 p. 261 - 274
