反应条件
1: 40 percent / acetic acid / H2O; methanol / 3 h / Heating
2: 82 percent / H2 / 10percent Pd/C / ethanol / 2 h / 50 °C / 1034.3 Torr
3: 1.) NaH / 1.) pentane, THF, RT, a) 1 h, reflux, b) 1 h, 2.) RT, 3 h
4: 1.) t-BuLi / 1.) THF, -78 deg C, 1 h, 2.) a.) -78 deg C, 10 min, b) RT, 1 h
5: 0.08 g / TFA / CH2Cl2 / 4 h / Ambient temperature
View Scheme
参考文献
Cheng, Alice C.; Shulgin, Alexander T.; Castagnoli, Neal
Journal of Organic Chemistry, 1982 , vol. 47, # 27 p. 5258 - 5262
