2-氯-4-硝基吡啶 N-氧化物合成路线 （共 29 条）
反应条件
1: 74 percent 2: 79 percent / conc. H2SO4, HNO3(D=1.4) / 0.5 h / 60 - 70 °C 3: 95 percent / PCl3 / CHCl3 / 1 h / Heating 4: 92 percent / 100percent N2H4 / ethanol / Heating 5: 28 percent / CH3COOAg / 1 h / Heating View Scheme
参考文献
Talik, Tadeusz; Talic, Zofia
Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 1 p. 84 - 88
反应条件
1: acetic acid; iron-powder / anschliessend mit Zink-Pulver unter Zusatz von wenig wss. HgCl2 2: NaNO2; aqueous H2SO4; CuSO4 / Diazotization.weitere Reagentien: Kupfer-Pulver, wss. Na2CO3 3: aqueous HCl View Scheme
参考文献
Talik; Plazek
Roczniki Chemii, 1955 , vol. 29, p. 1019,1025
Chem.Abstr., 1956 , p. 12045
反应条件
1: acetic acid; iron-powder / anschliessend mit Zink-Pulver unter Zusatz von wenig wss. HgCl2 2: sodium nitrite; aqueous sulfuric acid; copper (II)-sulfate; potassium bromide / 60 °C / Diazotization.Reagens 4: Kupfer-Pulver; Reagens 5: Wasser View Scheme
参考文献
Talik; Plazek
Roczniki Chemii, 1955 , vol. 29, p. 1019,1025
Chem.Abstr., 1956 , p. 12045
反应条件
1: ethanol 2: Fe / acetic acid View Scheme
参考文献
Sazonov,N.V. et al.
Pharmaceutical Chemistry Journal, 1972 , vol. 6, # 3 p. 146 - 149
Khimiko-Farmatsevticheskii Zhurnal, 1972 , vol. 6, # 3 p. 18 - 21
反应条件
1: acetic acid; iron-powder / anschliessend mit Zink-Pulver unter Zusatz von wenig wss. HgCl2 2: sodium nitrite; aqueous sulfuric acid; aqueous potassium iodide solution / Diazotization View Scheme
参考文献
Talik; Plazek
Roczniki Chemii, 1955 , vol. 29, p. 1019,1025
Chem.Abstr., 1956 , p. 12045
反应条件
hydrogenchloride; iron in ethanol Reduction; 3 h; Heating;
参考文献
Searls, Tim; McLaughlin, Larry W.
Tetrahedron, 1999 , vol. 55, # 41 p. 11985 - 11996
反应条件
potassium hydroxide; iron; acetic acid in diethyl ether; ethanol; water; Petroleum ether
参考文献
FMC Corporation
Patent: US4808722 A1, 1989 ;
反应条件
acetyl chloride T=70 - 75°C; 0.416667 h;
参考文献
Abramovitch, Rudolph A.; Deeb, Ali; Kishore, Dharma; Mpango, George B. W.; Shinkai, Ishiro
Gazzetta Chimica Italiana, 1988 , vol. 118, # 3 p. 167 - 172
反应条件
trichlorophosphate T=110°C; 2.5 h;
参考文献
Palmer, Andreas Marc; Muench, Gabriela; Brehm, Christof; Zimmermann, Peter Jan; Buhr, Wilm; Feth, Martin Philipp; Simon, Wolfgang Alexander
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 3 p. 1511 - 1530
反应条件
phosphorus trichoride in dichloromethaneu 4 h; Reflux;
参考文献
Jankowiak, Aleksandra; Kaszynski, Piotr
Journal of Organic Chemistry, 2009 , vol. 74, # 19 p. 7441 - 7448
