2,6-双(对-甲基苯)吡啶合成路线 （共 17 条）
反应条件
caesium carbonate; cesium fluoride in toluene; acetonitrile T=20 - 75°C; Inert atmosphere; Overall yield = 70 percent; Overall yield = 90.8 mg; regioselective reaction;
参考文献
European Journal of Organic Chemistry, , # 13 p. 2537 - 2540
反应条件
palladium diacetate; potassium carbonate; triphenylphosphine in toluene 12 h; RefluxInert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 15, # 47 p. 13105 - 13110
反应条件
dipotassium peroxodisulfate; silver nitrate; trifluoroacetic acid in dichloromethane; water T=23°C; 3 h;
参考文献
Seiple, Ian B.; Su, Shun; Rodriguez, Rodrigo A.; Gianatassio, Ryan; Fujiwara, Yuta; Sobel, Adam L.; Baran, Phil S.
Journal of the American Chemical Society, 2010 , vol. 132, # 38 p. 13194 - 13196
反应条件
1: 36 percent / K2CO3, tert-butyl hypochlorite / tetrahydrofuran / 0.25 h / 0 °C 2: 20 percent / tBuOK / 1,2-dimethoxy-ethane / 1.5 h / 0 °C View Scheme
参考文献
Chemische Berichte, , vol. 116, # 12 p. 3931 - 3946
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Schlenk technique; |Inert atmosphere 1.2: -90 - 20 °C / |Schlenk technique; |Inert atmosphere 2.1: potassium hydroxide; palladium diacetate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine / neat (no solvent) / 24 h / 110 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 18 p. 3553 - 3557
反应条件
1: sodium sulfate / tetrahydrofuran / 24 h / 20 °C / |Schlenk technique; |Inert atmosphere 2: potassium hydroxide; palladium diacetate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine / neat (no solvent) / 24 h / 110 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 18 p. 3553 - 3557
反应条件
1: NBS, benzoyl peroxide / CCl4 / 16 h / Heating 2: 78 percent / tetrahydrofuran; H2O / 1 h / Heating View Scheme
参考文献
Strekowski, Lucjan; Wilson, W. David; Mokrosz, Jerzy L.; Mokrosz, Maria J.; Harden, Donald B.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 580 - 588
