1: 6-chloro-9H-purin-2-ylamine With potassium carbonate in N,N-dimethyl-formamide 1 h; Inert atmosphere; 2: allyl bromide in N,N-dimethyl-formamide T=20°C; 48 h; Inert atmosphere;

potassium carbonate in N,N-dimethyl-formamide T=50°C; 16 h;

allyl halide Alkaline conditions;

tetrakis(triphenylphosphine) palladium(0); caesium carbonate 1.) DMSO, 45 deg C, 15 min, 2.) DMSO, 45 deg C, 23 h; Yield given. Multistep reaction. Yields of byproduct given;