(3S)-3-{[(苄氧基)羰基]氨基}-3-苯丙酸合成路线 （共 20 条）
反应条件
1.1: Fmoc-Cl; N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C 1.2: 84 percent / tetrahydrofuran; diethyl ether / 0 - 20 °C 2.1: 84 percent / silver benzoate / dioxane; H2O / 0.02 h / microwave irradiation View Scheme
参考文献
Kantharaju; Suresh Babu, Vommina V.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 10 p. 2152 - 2158
反应条件
2: 42 percent / 2 N NaOH / 0.17 h View Scheme
参考文献
Zemlicka; Bhuta
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 167 - 174
反应条件
3: 42 percent / 2 N NaOH / 0.17 h View Scheme
参考文献
Zemlicka; Bhuta
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 167 - 174
反应条件
1: sulfuric acid / 1 h / -10 - 5 °C / |Inert atmosphere; |Large scale 2: methanol / 40 °C / |Inert atmosphere; |Reflux; |Large scale 3: sodium carbonate / dichloromethane; water / 0 - 10 °C / |Inert atmosphere; |Large scale 4: sodium hydroxide / methanol; isopropyl alcohol / 2 h / 20 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
反应条件
1: methanol / 40 °C / |Inert atmosphere; |Reflux; |Large scale 2: sodium carbonate / dichloromethane; water / 0 - 10 °C / |Inert atmosphere; |Large scale 3: sodium hydroxide / methanol; isopropyl alcohol / 2 h / 20 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
反应条件
1: sodium carbonate / dichloromethane; water / 0 - 10 °C / |Inert atmosphere; |Large scale 2: sodium hydroxide / methanol; isopropyl alcohol / 2 h / 20 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
反应条件
1: ammonium formate / ethanol / 4 h / 20 - 65 °C / |Inert atmosphere; |Large scale 2: sulfuric acid / 1 h / -10 - 5 °C / |Inert atmosphere; |Large scale 3: methanol / 40 °C / |Inert atmosphere; |Reflux; |Large scale 4: sodium carbonate / dichloromethane; water / 0 - 10 °C / |Inert atmosphere; |Large scale 5: sodium hydroxide / methanol; isopropyl alcohol / 2 h / 20 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
参考文献
Sato,M.; Tatsuno,T.
Chemical and Pharmaceutical Bulletin, 1968 , vol. 16, # 11 p. 2182 - 2190
反应条件
boron trifluoride in tetrahydrofuran T=0 - 10°C; 3 h; Inert atmosphereLarge scale;
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
反应条件
1: benzene / 0.5 h / Heating 2: hydrogen / 10 percent Pd/charcoal / methanol / 5 h / Ambient temperature View Scheme
参考文献
Xie; Soleilhac; Schmidt; Peyroux; Roques; Fournie-Zaluski
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1497 - 1503
