2-[1-[2-[(4-甲脒基苯甲酰基)氨基]-3-(4-羟基苯基)丙酰]哌啶-4-基]氧基乙酸合成路线 （共 12 条）
反应条件
1: thionyl chloride / tetrahydrofuran; dimethylformamide / 20 °C 2: tetra-n-butylammonium hydrogen sulfate, aq. NaHCO3 / CH2Cl2 / 16 h / Ambient temperature 3: trifluoroacetic acid (TFA) / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Alig; Edenhofer; Hadvary; Hurzeler; Knopp; Muller; Steiner; Trzeciak; Weller
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4393 - 4407
反应条件
1: tetra-n-butylammonium hydrogen sulfate, aq. NaHCO3 / CH2Cl2 / 16 h / Ambient temperature 2: trifluoroacetic acid (TFA) / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Alig; Edenhofer; Hadvary; Hurzeler; Knopp; Muller; Steiner; Trzeciak; Weller
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4393 - 4407
