1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.08 h / 0 - 20 °C 2.1: potassium phosphate; ethanol / 10 h / 70 °C 3.1: sodium hydride / ethylene glycol dimethyl ether / 0.17 h / 0 °C / |Schlenk technique 3.2: 1 h / 20 °C / |Schlenk technique 4.1: potassium phosphate; palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / tert-butyl alcohol / 12 h / 90 °C / |Inert atmosphere; |Schlenk technique 5.1: Ni(PCy3)2Cl2; tri-cyclo-hexyl-phosphine; potassium carbonate / 1,4-dioxane / 24 h / 120 °C / |Inert atmosphere; |Schlenk technique 6.1: Ni(PCy3)2Cl2 / toluene / 24 h / 130 °C / |Inert atmosphere; |Schlenk technique View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8128150', constants.ctx, '0')">sodium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=20&deg;C;&nbsp;36&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.33 h / 0 - 20 &deg;C<br />2: sodium hydroxide; water / N,N-dimethyl-formamide / 36 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.33 h / 0 - 20 &deg;C<br />2: sodium hydroxide; water / N,N-dimethyl-formamide / 36 h / 20 &deg;C<br /> <br /> &nbsp;