1: 2-(2-thienyl)ethanol benzenesulfonate; (S)-α-amino-(2-chlorophenyl)acetic acid With sodium hydrogencarbonate in anhydrous propionitrile Heating; 2: formaldehyd With formic acid T=40°C; 3 h; 3: With sodium hydroxide in dichloromethane; water T=0°C; pH=~ 6; Product distribution / selectivity;
参考文献
KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO
Patent: WO2008/34912 A2, 2008 ;
Location in patent: Page/Page column 3; 40-41 ;