1: 60 percent / NEt3, NaI / acetonitrile / 15 h / 85 °C 2: 80 percent / NaN(SiMe3)2 / tetrahydrofuran / -100 deg C to RT 3: TsOH / tetrahydrofuran; H2O / 0.17 h 4: 50 percent / NaN(SiMe3)2 / tetrahydrofuran / -100 deg C to RT 5: 92 percent / LiOH / tetrahydrofuran / 15 h / Ambient temperature View Scheme

1: 60 percent / NEt3, NaI / acetonitrile / 15 h / 85 °C 2: 80 percent / NaN(SiMe3)2 / tetrahydrofuran / -100 deg C to RT 3: TsOH / tetrahydrofuran; H2O / 0.17 h 4: 50 percent / NaN(SiMe3)2 / tetrahydrofuran / -100 deg C to RT View Scheme