1-(吡啶-2-基)哌啶-4-胺合成路线 （共 6 条）
反应条件
trifluoroacetic acid in dichloromethane 1 h;
参考文献
WO2009/60158 A1, ;
Page/Page column 15-16 ;
WO 2009/060158 A1
反应条件
nitrogen; caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane; hexane; ethyl acetate
参考文献
US2004/259843 A1, ;
US2005/215784 A1, ;
US 20050215784 A1
反应条件
hydrogenchloride in methanol
参考文献
US2002/91116 A1, ;
US6632815 B2, ;
反应条件
10 platinum on carbon; hydrogen in methanol T=30°C; Flow reactor;
参考文献
ACS Combinatorial Science, , vol. 15, # 9 p. 503 - 511
反应条件
1: hydrogenchloride / 1,4-dioxane / 60 °C 2: potassium carbonate / dimethyl sulfoxide / 18 h / 90 °C 3: hydrogen; 10 platinum on carbon / methanol / 30 °C / |Flow reactor View Scheme
参考文献
ACS Combinatorial Science, , vol. 15, # 9 p. 503 - 511
反应条件
in dichloromethane T=20°C; 0.75 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/121919 A1, 2007 ;
Location in patent: Page/Page column 40-41 ;
WO 2007/121919 A1
