1: 1.) LiHMDS, 2.) I2 / 1.) THF, 0 deg C, 1 h, 2.) THF, 1 h 2: 85 percent / aq. HCl / methanol / 5 h / Heating View Scheme

(+)-(2S,8aS)-(camphorylsulfonyl)oxaziridine; lithium chloride; lithium diisopropyl amide 1) -42 deg C, 2) -100 to -78 deg C; Yield given. Multistep reaction. Yields of byproduct given;

<b>Multi-step reaction with 3 steps<br /> </b>1: 58 percent / aq. NaOH / 0.5 h / 20 &deg;C<br />2: 40 percent / isobutyl chloroformate; Et₃N / CH₂Cl₂ / 0.67 h / -15 - 20 &deg;C<br />3: (S)-BnNMe-C(O)-CH(t-Bu)-NHC(S)NH-[(R,R)-2-NMe₂-cyclohexyl] / toluene / 24 h / 20 &deg;C<br /> <br /> &nbsp;