(S)-(-)-1-苯基乙醇合成路线 （共 393 条）
反应条件
1: With (Sa)-2'-[(R)-hydroxy(phenyl)methyl]-(1,1'-binaphthalen)-2-ol; titanium (IV) isopropoxide in toluene T=-40°C; 1 h; Inert atmosphere; 2: With hydrogenchloride in water Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Fernandez-Mateos, Emilio; MacIa, Beatriz; Yus, Miguel
European Journal of Organic Chemistry, 2012 , # 20 p. 3732 - 3736
反应条件
toluene-4-sulfonic acid in methanol 3 h;
参考文献
Noe, Christian R.
Chemische Berichte, 1982 , vol. 115, # 4 p. 1591 - 1606
反应条件
NiCl2((PPh3)P)2 in toluene
参考文献
Taniguchi, Takahiko; Ogasawara, Kunio
Chemical Communications, 1998 , # 15 p. 1531 - 1532
反应条件
1-[(Ph2C(OH)]-2-[(S)-4-(t-Bu)oxazolin-2-yl]ferrocene in toluene T=0°C; Addition; 15 h; Title compound not separated from byproducts;
参考文献
Chemical Communications, , # 14 p. 1295 - 1296
反应条件
sodium hydroxide; hydrogen; palladium on activated charcoal in ethanol T=20°C; Hydrogenation; Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 16 p. 2397 - 2402
反应条件
Candida antarctica lipase B in diethyl ether T=20°C; 4 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Tetrahedron Asymmetry, , vol. 20, # 10 p. 1191 - 1196
反应条件
Candida antarctica lipase B in diethyl ether T=20°C; 34 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Tetrahedron Asymmetry, , vol. 20, # 10 p. 1191 - 1196
反应条件
ruthenium trichloride in toluene T=79.84°C; P=760.051 Torr; 5 h; Inert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 14, # 36 p. 11480 - 11487
反应条件
1: With Candida antarctica lipase B in tert-butyl methyl ether T=30°C; 16 h; Enzymatic reaction; 2: With hydrogenchloride; water in methanol; tert-butyl methyl ether T=30°C; 1 h; optical yield given as percent ee;
参考文献
Brossat, Maude; Moody, Thomas S.; Nanteuil, Florian De; Taylor, Stephen J.C.; Vaughan, Fatima
Organic Process Research and Development, 2009 , vol. 13, # 4 p. 706 - 709
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=20°C; Inert atmosphere; 2: With immobilized Candida antarctica Lipase B; water in hexane T=30°C; pH=6.5; 72 h; aq. phosphate bufferEnzymatic reaction; 3: With water; sodium hydroxide in methanol T=20°C; 1 h; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron, , vol. 66, # 40 p. 8060 - 8067
