(S)-(-)-1-苯基乙醇合成路线 （共 393 条）
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=20°C; Inert atmosphere; 2: With immobilized Candida antarctica Lipase B; water in hexane T=30°C; pH=6.5; 24 h; aq. phosphate bufferEnzymatic reaction; 3: With water; sodium hydroxide in methanol T=20°C; 1 h; optical yield given as percent eeenantioselective reaction;
参考文献
Okudomi, Masayuki; Ageishi, Kanpei; Yamada, Tomomi; Chihara, Naoka; Nakagawa, Takuya; Mizuochi, Katsumi; Matsumoto, Kazutsugu
Tetrahedron, 2010 , vol. 66, # 40 p. 8060 - 8067
反应条件
in isopropyl alcohol
参考文献
EP2281581 B1, ;
Page/Page column ;
反应条件
β-galactosidase in various solvent(s) T=35°C;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 12 p. 5547 - 5550
反应条件
toluene-4-sulfonic acid in chloroform 2 h;
参考文献
Noe, Christian R.; Knollmueller, Max; Wagner, Ernst; Voellenkle, Horst
Chemische Berichte, 1985 , vol. 118, # 8 p. 3299 - 3310
反应条件
in hexane 3 h; Ambient temperaturebiocatalyst: lipase SP625 from Candida antarctica;
参考文献
Tetrahedron Letters, , vol. 38, # 3 p. 387 - 388
反应条件
(R)-4-(diphenylhydroxymethyl)-1,3-thiazolidine 1.) toluene, from -20 deg C to RT, 2.) toluene, RT, 16 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 8, # 12 p. 2033 - 2043
反应条件
[(C4Ph4COHOCC4Ph4)(μ-H)][(CO)4Ru2]; Novozym(R) 435; 2,4-dimethylpentan-3-one in toluene T=70°C; P=142.511 Torr; 40 h;
参考文献
Verzijl, Gerard K.M.; De Vries, Johannes G.; Broxterman, Quirinus B.
Tetrahedron Asymmetry, 2005 , vol. 16, # 9 p. 1603 - 1610
反应条件
Candida antarctica lipase B in diethyl ether T=20°C; 144 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Tetrahedron Asymmetry, , vol. 20, # 10 p. 1191 - 1196
反应条件
1: sec-phenethyl alcohol With iPr2NCHEt2; (-)-Tetramisole in tetrahydrofuran T=-78°C; 0.5 h; Molecular sieveInert atmosphereResolution of racemate; 2: triphenyl-silyl chloride in tetrahydrofuran T=-78°C; Inert atmosphereResolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Organic Letters, , vol. 13, # 15 p. 3794 - 3797
反应条件
lipase B; hydrogen T=50°C; P=4200.42 Torr; 5 h; Enzymatic reaction;
参考文献
Research on Chemical Intermediates, , vol. 36, # 3 p. 245 - 252
