(S)-(-)-1-苯基乙醇合成路线 （共 393 条）
反应条件
50 U aminoacylase E.C. 3.5.1.14 in hexane T=20°C; Acylation; 144 h;
参考文献
Tetrahedron Asymmetry, , vol. 11, # 8 p. 1801 - 1808
反应条件
sodium hydroxide in tetrahydrofuran T=20°C; Hydrolysis; 18 h;
参考文献
Tetrahedron Asymmetry, , vol. 11, # 6 p. 1279 - 1288
反应条件
1,3-di[(R)-(+)-α-methylbenzyl]imidazolium tetrafluoroborate; potassium tert-butylate in tetrahydrofuran T=-78°C; 1 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Organic Letters, , vol. 7, # 7 p. 1347 - 1349
反应条件
1,3-di[(R)-(+)-α-methylbenzyl]imidazolium tetrafluoroborate; potassium tert-butylate in tetrahydrofuran T=-78°C; 1 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Organic Letters, , vol. 7, # 7 p. 1347 - 1349
反应条件
1,3-di[(R)-(+)-α-methylbenzyl]imidazolium tetrafluoroborate; potassium tert-butylate in tetrahydrofuran T=-78°C; 3 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Organic Letters, , vol. 7, # 7 p. 1347 - 1349
反应条件
Novozym 435; Zr-beta in various solvent(s) T=60°C; 6 h;
参考文献
Zhu, Yongzhong; Fow, Kam-Loon; Chuah, Gaik-Khuan; Jaenicke, Stephan
Chemistry - A European Journal, 2007 , vol. 13, # 2 p. 541 - 547
反应条件
1: 39 percent / (+)-(1S,2R)-norephedrine; KOH / [RuCl2(η6-benzene)]2 / propan-2-ol / 20 °C 2: (-)-ephedrine; KOH / [RuCl2(η6-benzene)]2 / propan-2-ol / 20 °C View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 690, # 13 p. 3176 - 3186
反应条件
1.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.5 h / 80 °C 1.2: tetrahydrofuran / 1 h / -78 °C 2.1: MgSO4 / toluene / 20 °C 3.1: H2 / [Rh(cod)2]BF4; (R)-(+)-BINAP / 1,2-dichloro-ethane / 168 h / -20 °C / 6840 Torr 3.2: NaOAc; H2O2 / 2 h / 20 °C View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 642, # 1-2 p. 145 - 147
反应条件
1.1: MgSO4 / toluene / 20 °C 2.1: H2 / [Rh(cod)2]BF4; (R)-(+)-BINAP / 1,2-dichloro-ethane / 168 h / -20 °C / 6840 Torr 2.2: NaOAc; H2O2 / 2 h / 20 °C View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 642, # 1-2 p. 145 - 147
反应条件
1: 30 percent / bakers' yeast / ethanol; H2O / 48 h / 30 °C 2: 85 percent / N-benzyl-1,4-dihydronicotinamide / RhCl(PPh3)3 / acetonitrile View Scheme
参考文献
Tetrahedron Letters, , vol. 25, # 36 p. 3979 - 3982
