(S)-(-)-1-苯基乙醇合成路线 （共 393 条）
反应条件
1: H2 / (-)-2,3-O-isopropylidene-1,4-bis(diphenylphosphino)-2,3-butanediol <(-)-DIOP> / benzene / 40 h / 20 °C / 3800 Torr 2: 1.) MeLi 2.) H3O(1+) / 1.) ether View Scheme
参考文献
Tetrahedron Letters, , vol. 22, # 44 p. 4417 - 4420
反应条件
Candida antarctica lipase B in diethyl ether T=20°C; 90 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Tetrahedron Asymmetry, , vol. 20, # 10 p. 1191 - 1196
反应条件
Candida antarctica lipase B in diethyl ether T=20°C; 43 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Chenevert, Robert; Pelchat, Nicholas; Morin, Pierre
Tetrahedron Asymmetry, 2009 , vol. 20, # 10 p. 1191 - 1196
反应条件
Pseudomonas cepacia lipase immobilized on 1-pyrenebutyric acid N-hydroxysuccinimide ester-functionalized single walled carbon nanotubes in 1-butyl-3-methylimidazolium tetrafluoroborate in toluene T=25°C; 8 h; optical yield given as percent ee;
参考文献
Lee, Han Ki; Lee, Jae Kwan; Kim, Mahn-Joo; Lee, Cheol Jin
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 3 p. 650 - 652
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=20°C; Inert atmosphere; 2: With immobilized Candida antarctica Lipase B; water in hexane T=30°C; pH=6.5; 24 h; aq. phosphate bufferEnzymatic reaction; 3: With water; sodium hydroxide in methanol T=20°C; 1 h; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron, , vol. 66, # 40 p. 8060 - 8067
反应条件
(1R,2R,1'R,1''R)-N,N'-di(1-phenylethyl)-1,2-cyclohexanediamine; (Ph)2SiH2; diethylzinc in toluene T=0 - 20°C; optical yield given as percent eeenantioselective reaction;
参考文献
Organic and Biomolecular Chemistry, , vol. 8, # 17 p. 3992 - 3996
反应条件
water; potassium hydroxide in methanol T=65°C; 2 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 2 p. 559 - 570
反应条件
lipase-lipide in 2,2,4-trimethylpentane T=40°C; Product distributionRate constant;
参考文献
Tetrahedron Letters, , vol. 29, # 40 p. 5133 - 5134
反应条件
KNO2; 18-crown-6 ether; N,N-dimethyl-formamide in dimethyl sulfoxide T=0°C; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 9, # 4 p. 681 - 689
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 12, # 12 p. 1801 - 1806
