(S)-(-)-1-苯基乙醇合成路线 （共 393 条）
反应条件
1: Br2AlH / diethyl ether / 1.) -78 deg C, 1 h; 2.) 0 deg C, 0.5 h 2: 1.) oxalyl chloride/DMSO; 2.) Et3N / CH2Cl2 / 1.) -78 deg C, 17 min; 2.) a.) -78 deg C, 5 min; b.) RT, 30 min 3: K2CO3 / methanol / 12 h / Ambient temperature View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 285, p. 83 - 94
反应条件
1: 90 percent Spectr. / diborane / toluene / -78 °C 2: Raney Ni View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 7 p. 1196 - 1200
反应条件
1: 1.) n-BuLi / 1.) THF, 0 deg C, 15 min, 2.) room temp., overnight 2: 90 percent Spectr. / diborane / toluene / -78 °C 3: Raney Ni View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 7 p. 1196 - 1200
反应条件
1: With (4R,5R)-DIOP; [{RhCl(cod)}2] in tetrahydrofuran T=20°C; 4 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; water optical yield given as percent ee;
参考文献
Marques, Carolina S.; Burke, Anthony J.
Synthetic Communications, 2008 , vol. 38, # 23 p. 4207 - 4214
反应条件
1: With tetracarbonylbis(μ-chloro)dirhodium(I); (R)-(+)-bornylamine in tetrahydrofuran T=0 - 2°C; 2: With hydrogenchloride; water in methanol optical yield given as percent eeenantioselective reaction;
参考文献
Russian Journal of General Chemistry, , vol. 80, # 1 p. 35 - 46
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=20°C; Inert atmosphereAnhydrous conditions; optical yield given as percent eeenantioselective reaction;
参考文献
European Journal of Organic Chemistry, , # 14 p. 2696 - 2700
反应条件
1: With C38H31Cl2N3O4PRe in 1,4-dioxane T=20°C; 2: With tetrabutyl ammonium fluoride in 1,4-dioxane T=20°C; optical yield given as percent eeenantioselective reaction;
参考文献
Chemistry - A European Journal, , vol. 16, # 31 p. 9555 - 9562
反应条件
1: With CF3O3S(1-)*C45H39N2OPRh(1+); benzo[1,3,2]dioxaborole in tetrahydrofuran T=20°C; 2 h; Inert atmosphere; 2: With dihydrogen peroxide; sodium hydroxide in ethanol; water T=0 - 20°C; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 21, # 11-12 p. 1458 - 1473
反应条件
CAL B T=35°C; P=100 Torr; 168 h; Ionic liquidResolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
European Journal of Organic Chemistry, , # 36 p. 6938 - 6943
反应条件
(R)-(+)-N-methylbenzoguanidine; trimethylacetic anhydride in diethyl ether T=20°C; 12 h; Resolution of racemate; optical yield given as percent ee;
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 20 p. 7092 - 7096
