(S)-(-)-1-苯基乙醇合成路线 （共 393 条）
反应条件
1: pyridinium p-toluenesulfonate / benzene / 0.5 h / Heating 2: Br2AlH / diethyl ether / 1.) -78 deg C, 1 h; 2.) 0 deg C, 0.5 h 3: 1.) oxalyl chloride/DMSO; 2.) Et3N / CH2Cl2 / 1.) -78 deg C, 17 min; 2.) a.) -78 deg C, 5 min; b.) RT, 30 min 4: K2CO3 / methanol / 12 h / Ambient temperature View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 285, p. 83 - 94
反应条件
1: BF3 / diethyl ether / 0.25 h / -55 °C 2: oxalyl chloride/DMSO / CH2Cl2 3: KOH / tetrahydrofuran; methanol / 15 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 45, # 2 p. 507 - 516
反应条件
Tris-HCl buffer T=30°C; pH=7.5; 24 h; Enzymatic reaction; enantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 74, # 4 p. 1730 - 1732
反应条件
Burkholderia cepacia lipase; C13H24N3(1+)*C36H73O14S(1-) in di-isopropyl ether T=35°C; 0.5 h; Kinetics; Reagent/catalystTime; optical yield given as percent eeenantioselective reaction;
参考文献
Abe, Yoshikazu; Hirakawa, Takuya; Nakajima, Shino; Okano, Nagisa; Hayase, Shuichi; Kawatsura, Motoi; Hirose, Yoshihiko; Itoh, Toshiyuki
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 13 p. 1954 - 1958
反应条件
Eutypa lata; PDB medium in ethanol T=25°C; 192 h; Microbiological reaction; optical yield given as percent ee;
参考文献
Tetrahedron Asymmetry, , vol. 20, # 23 p. 2666 - 2672
反应条件
1: methylmagnesium bromide With Pseudoephedrine; methyllithium in tetrahydrofuran T=20°C; 2 h; Inert atmosphere; 2: benzaldehyde in tetrahydrofuran T=-78°C; 1 h; Inert atmosphere; 3: With water; ammonium chloride in tetrahydrofuran T=-78°C; Inert atmosphere;
参考文献
Bailey, William F.; Luderer, Mark R.
Arkivoc, 2010 , vol. 2010, # 8 p. 108 - 115
反应条件
Birman's catalyst; trimethylacetic anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 12 h; optical yield given as percent eeenantioselective reaction;
参考文献
Heterocycles, , vol. 77, # 2 p. 801 - 810
反应条件
Birman's catalyst; trimethylacetic anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 12 h; optical yield given as percent eeenantioselective reaction;
参考文献
Heterocycles, , vol. 77, # 2 p. 801 - 810
反应条件
Novozym 435 in toluene T=70°C; 3 h; Resolution of racemateContinuous-flow reactor;
参考文献
Organic Process Research and Development, , vol. 14, # 2 p. 351 - 361
反应条件
(5aS,10bR)-5a,10b-dihydro-2-(pentafluorophenyl)-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazinium tetrafluoroborate; 3-benzylriboflavin tetraacetate; triethylamine in toluene T=20°C; 19 h; Resolution of racemateAirMolecular sieve; optical yield given as percent eeenantioselective reaction;
参考文献
Chemistry - A European Journal, , vol. 17, # 29 p. 8009 - 8013
