6,9-二氟苯并异喹啉-5,10-二酮合成路线 （共 7 条）
参考文献
THE UNIVERSITY OF VERMONT
Patent: EP503537 A1, 1992 ;
反应条件
sulfuric acid; sulfur trioxide T=130 - 135°C; 0.5 h;
参考文献
Krapcho, A. Paul; Gallagher, Cynthia E.; Hammach, Abdelhakim; Ellis, Michael; Menta, Ernesto; Oliva, Ambrogio
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 1 p. 27 - 32
反应条件
aluminium trichloride; sulfuric acid 1.) reflux, 22 h, 2.) from 135 to 140 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 6 p. 828 - 837
反应条件
1: 76 percent / acetic anhydride / 2 h / Heating 2: 1.) AlCl3, 2.) f.H2SO4 / 1.) reflux, 22 h, 2.) from 135 to 140 deg C, 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 6 p. 828 - 837
反应条件
lithium diisopropyl amide 1.) hexane, THF, -78 deg C, 10 min, 2.) hexane, THF, -40 deg C to r.t.; Yield given. Multistep reaction;
参考文献
Journal of Fluorine Chemistry, , vol. 68, # 2 p. 131 - 134
参考文献
US2005/222190 A1, ;
Page/Page column 5 ;
反应条件
in pyridine 1.) RT, 12 h, 2.) 50 deg C, 2 h;
参考文献
Krapcho, A. Paul; Petry, Mary E.; Getahun, Zelleka; Landi, John J.; Stallman, John; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 6 p. 828 - 837
