1,4-diaza-bicyclo[2.2.2]octane in chloroform T=60°C; 72 h;

in water; acetonitrile 24 h; Ambient temperature;

1: in ethanol; water T=20°C; 168 h; 2: in ethanol; water 5 h; Reflux;

in methanol T=110 - 112°C; 2 h; Green chemistry;

1.1: sodium methylate / methanol / 0.25 h / 0 °C / |Green chemistry 1.2: 4 h / 0 °C / |Green chemistry 1.3: 2 h / |Reflux; |Green chemistry 2.1: methanol / 2 h / 110 - 112 °C / |Green chemistry View Scheme

1: With sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran; diethyl ether T=20°C; 0.5 h; Inert atmosphere; 2: 5-phenylisoxazole-3-(N-methyl)carboxamide in tetrahydrofuran; diethyl ether 4 h; Reflux; Further stages;