4-溴-2,2-二氟-1,3-苯并二恶茂合成路线 （共 3 条）
反应条件
bromine; sec.-butyllithium in tetrahydrofuran; cyclohexane T=-75°C; 2 h;
参考文献
Schlosser, Manfred; Gorecka, Joanna; Castagnetti, Eva
European Journal of Organic Chemistry, 2003 , # 3 p. 452 - 462
反应条件
in tetrahydrofuran; biphenyl; pentane T=-75.16°C; Inert atmosphere; Equilibrium constant;
参考文献
Gorecka-Kobylinska, Joanna; Schlosser, Manfred
Journal of Organic Chemistry, 2009 , vol. 74, # 1 p. 222 - 229
反应条件
1: 4-bromo-2,2-difluoro-1,3-benzodioxole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: boric acid trimethyl ester in tetrahydrofuran; hexane T=-78 - 20°C; 2 h; 3: With hydrogenchloride; water in tetrahydrofuran; hexane T=0 - 20°C; 0.333333 h;
参考文献
WO2008/148853 A1, ;
Page/Page column 86 ;
WO 2008/148853 A1
