1.1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 40 - 45 °C 2.1: water; sodium hydroxide / methanol / 1 h / 60 - 65 °C 3.1: triethylamine / dichloromethane / 24 h / 25 - 35 °C 4.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 25 - 45 °C 5.1: methylamine / methanol / 60 - 65 °C 5.2: 1.5 h / 25 - 65 °C / pH 5.5 - 6.0 6.1: sodium carbonate / water; dichloromethane / 0 - 35 °C View Scheme