1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C 2: hydrogen; palladium 10 on activated carbon / methanol / 1 h / 20 °C View Scheme

trifluoroacetic acid in dichloromethane T=20°C; 17 h;

<b>Multi-step reaction with 4 steps<br /> </b>1.1: sodium tetrahydroborate; cobalt(II) chloride / methanol / 24 h / 0 - 20 &deg;C / |Inert atmosphere<br />1.2: 3 h / |Inert atmosphere<br />2.1: Lawesson's reagent / tetrahydrofuran / 17 h / 20 &deg;C / |Inert atmosphere<br />3.1: hydrogen / water; tetrahydrofuran / 2 h / 20 &deg;C / |Inert atmosphere<br />4.1: sodium hydroxide / water / 16 h / 20 &deg;C / pH 8 - 10<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: hydrogen / water; tetrahydrofuran / 2 h / 20 &deg;C / |Inert atmosphere<br />2: sodium hydroxide / water / 16 h / 20 &deg;C / pH 8 - 10<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '8128150', constants.ctx, '0')">sodium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=20&deg;C;&nbsp;pH=8 - 10;&nbsp;16&nbsp;h;&nbsp;<br /> &nbsp;